The Cognitive Safety of Deep Brain Stimulation in Refractory Psychiatric Disorders
نویسندگان
چکیده
Over the last decade, deep brain stimulation (DBS) has revolutionized the treatment of movementdisorders and is now being used experimentally to treat refractory psychiatric disorders as well. DBS is a neurosurgical treatment involving the implantation of electrodes, which send electricity to specific targets deep in the brain. DBS in psychiatric disorders such as Tourette syndrome (TS), obsessive-compulsivedisorder (OCD), major depression (MD) is based on focal neuromodulation of cortico-basal ganglia-thalamocortical loops involved in the control of behaviour and emotions paralleling the effect of modulating the motor circuit to treat movement disorders such as Parkinson’s Disease (PD). DBS has crucial advantages over ablative procedures, performed mainly in the past, since it is reversible and adjustable [1]. However, it is not without risks and its cognitive safety is questionable. This study reviews the cognitive outcome of DBS in refractory TS, OCD and MD. We searched PubMed and Medline for articles in English published up to December 2011 using combinations of the following terms: neuropsychological, cognitive, executive function, memory, attention, deep brain stimulation, neurosurgery, stereotaxy, TS, tics, OCD, MD, anxiety and mood. The retrieved abstracts were reviewed and the reference sections of the selected articles were screened for relevant studies.
منابع مشابه
O10: Deep Brain Stimulation and Psychiatry
The use of deep brain stimulation in psychiatric disorders has received great interest owing to the small risk of the operation, the reversible nature of the technique, and the possibility of optimizing treatment postoperatively. Currently deep brain stimulation in psychiatry is investigated for obsessive-compulsive disorder, Gilles de la Tourette’s syndrome and major depression. This presentat...
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[Deep brain stimulation in psychiatry].
BACKGROUND Deep brain stimulation (DBS) is now used regularly to treat therapy-refractory obsessive-compulsive disorders, and is being applied experimentally for refractory depression, Tourette syndrome, addiction, eating disorders, post-traumatic stress disorder, autism and schizophrenia. AIM To review the effects and mechanisms of dbs and to consider the future opportunities for this type o...
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